SciELO - Scientific Electronic Library Online

vol.15 número1Tendencia de niños y niñas de 6 años libres de caries en Chile entrelos años 2012 y 2019.Análisis de los fundamentos biológicos del Sistema Ertty Gap III® índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


International journal of interdisciplinary dentistry

versión impresa ISSN 2452-5596versión On-line ISSN 2452-5588


NEGRO, Gastón et al. Identification of macrophages and Epstein-Barr virus in salivary glands of Sjögren’s syndrome patients. Int. j interdiscip. dent. [online]. 2022, vol.15, n.1, pp.39-43. ISSN 2452-5596.

Sjögren’s syndrome (SS) is an immunologically mediated chronic disease of complex etiopathogenesis. Macrophages and Epstein-Barr virus are among the factors related to its development and severity. Macrophages contribute to the local autoimmune process and viral infection promotes the breakdown of self-tolerance.


Identify the presence of macrophages in the inflammatory infiltrate and Epstein-Barr virus in inflammatory cells, correlating them with the histological features of labial salivary glands.


In labial salivary glands biopsies of 8 patients and 7 control individuals, anti-CD-68 immunohistochemistry was performed to identify macrophages. The macrophages and inflammatory cells were counted in relation to their distribution in the salivary glands. The presence of the virus was evaluated by in situ hybridization for viral RNA and immunohistochemistry for latent membrane protein type 1. The comparison between both groups was made using the unpaired t-test and Mann-Whitney test. The correlations with histological parameters were established with the Pearson´s correlation coefficient.


A greater number of macrophages was observed in the inflammatory infiltrate of SS patients (p=0,001**). Macrophages in control individuals were diffusely distributed in the gland, while, SS in patients, they were mainly located in inflammatory foci. In both groups, no inflammatory or epithelial cells infected by the Epstein-Barr virus were identified.


Patients with Sjögren’s syndrome had a greater presence of macrophages and their increase is at the expense of the inflammatory focus.

Palabras clave : Sjögren’s syndrome; Labial salivary gland; Macrophages; Epstein-Barr virus.

        · resumen en Español     · texto en Español     · Español ( pdf )