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International journal of interdisciplinary dentistry

versión impresa ISSN 2452-5596versión On-line ISSN 2452-5588


ROSENBERG, D; MARTINEZ, B; CARRASCO, N  y  GALVAN, T. Effect of Dentoxol® in the treatment of recurrent mild aphthous ulcers. A prospective observational pilot study. Int. j interdiscip. dent. [online]. 2022, vol.15, n.1, pp.25-28. ISSN 2452-5596.


Recurrent aphthous stomatitis (RAS) is the most common oral ulceration. Its prevalence in the general population varies between 5% and 60%, and during the acute period, it causes pain and interferes with basic activities, such as eating, swallowing and talking. Dentoxol® is a medical mouthrinse that cleans, moisturizes and lubricates the mouth, mechanically stimulating local epithelial regeneration. The aim of this study was to evaluate the efficacy of Dentoxol® in improving the general state of patient with minor RAS using two different treatment schemes.

Material and methods:

Thirty-nine patients with RAS were recruited in a prospective observational pilot study. Two dosing regimens, 5 ml of Dentoxol® twice daily and 5 ml of Dentoxol® three times daily were evaluated.


Efficacy to improve the general state was significant superior in “Three time daily” group compared with “twice daily” at 72 h (66% vs 33% respectively). No pain was reported in approximately 90% of cases at 96 h of use in both group without significant differences between the groups in any evaluation time-point.


Despite the limitations of these preliminary data, Dentoxol® shows promising beneficial properties for the management of minor RAS.

Palabras clave : Recurrent aphthous stomatitis; Mouthrinse; Dentoxol.

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