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Revista clínica de periodoncia, implantología y rehabilitación oral

On-line version ISSN 0719-0107


URZUA-ORELLANA, Blanca et al. Effect of miconazole on the yeast count in candidiasis associated with denture stomatitis. Rev. Clin. Periodoncia Implantol. Rehabil. Oral [online]. 2018, vol.11, n.2, pp.102-105. ISSN 0719-0107.


Denture stomatitis is a chronic inflammatory process of the mucosa adjacent to removable prosthesis. 71.4% of the subjects with this condition are carriers of Candida and the severity is related to the presence of this yeast. Topical antimycotics belonging to the polyene or azole family are indicated for its treatment. Efficacy of miconazole is reported to be from 80% to 100%, although resistance is described in isolates of Candida. The purpose of the study was to determine the count of Candida in older adults with oral candidiasis, before and after being treated with miconazole.


Systemic and local antecedents were recorded in 32 elderly adults with denture stomatitis. Differences in number of the colony forming units of Candida yeast, were determined before and after topical treatment with Miconazole 2%. Statistical significances were set at a value of p < 0.05.


Yeast counts at the start of the study significantly decreased 8 and 15 days after treatment (median 6,800, 163, 60, respectively). 56.2% of the subjects presented persistence of yeasts after treatment; 21.8% of them with counts higher than 400 CFU / ml saliva.


In 56.2% of the study subjects, persistence of Candida yeasts was observed after 2 weeks of treatment with 2% miconazole.

Keywords : Denture stomatitis; Yeast; Candida; Miconazole.

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