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Revista chilena de cardiología

versión On-line ISSN 0718-8560

Resumen

VARASTEHRAVAN, Hamidreza; KARBALAEI TAFTI, Seyed Saeed; NOUGH, Hossein  y  NAGHEDI, Aryan. Relationship between mean platelet volume and gravity of coronary artery disease. Rev Chil Cardiol [online]. 2019, vol.38, n.3, pp.182-189. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602019000300182.

Background and aim:

Platelets play a principal role in pathogenesis of coronary artery diseases. Mean platelet volume (MPV) is an indicator of circulating platelet size and has been demonstrated to be correlated with platelet activity. The aim of the current study was to investigate whether MPV is associated with the severity of coronary artery disease.

Methods:

We measured MPV in 910 consecutive patients with symptomatic acute coronary syndrome undergoing coronary angiography. The basic data of patients were collected. Significant coronary artery disease was defined as >50% stenosis in at least 1 coronary artery and severe coronary artery disease was defined as three vessel disease and/or left main artery disease.

Results:

This study included 477 (52.4%) males and 433(47.6%) females. A significant relationship between MPV and severity of coronary artery disease (p= 0.001) was found. Logistic regression analysis confirmed that each unit increment in mean platelet volume was associated to a 4.67% increase in the in the risk of severe coronary artery disease. In addition, we found that MPV was higher in males and in cigarette smokers.

Conclusion:

This study showed that MPV is related to severity of coronary artery disease. MPV might be a useful parameter for primary evaluation of severity of coronary artery involvement in patients with symptoms of coronary artery diseases.

Palabras clave : coronary artery disease; mean platelet volume; coronary angiography.

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