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Revista chilena de cardiología

On-line version ISSN 0718-8560

Abstract

ALEMAN, Larissa; RAMIREZ-SAGREDO, Andrea; ORTIZ-QUINTERO, Jafet  and  LAVANDERO, Sergio. Type II Diabetes and Ischemic Heart disease: pathophysiology, gen regulation and future therapeutic options. Rev Chil Cardiol [online]. 2018, vol.37, n.1, pp.42-54. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602018000100042.

In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic and affects millions of people worldwide. Ischemic heart disease (IHD) is the main cause of death among diabetic patients, who have a higher cardiovascular risk than non-diabetics. Both, DM2 and IHD are characterized by being preventable, however there are several common risk factors that contribute to their development.

The mechanisms that explain accelerated atherosclerosis and increased risk of cardiovascular diseases in patients with type 2 diabetes mellitus include damage by hyperglycemia, dyslipidemia and inflammation on vascular endothelium.

Diabetes is the result of a complex interaction between genetics and the environment, recently, several genes have been identified that appear to be involved in diabetes and ischemic heart disease that could explain its relationship and serve as new therapeutic possibilities.

In this article, we review the relationship between diabetes and ischemic heart disease, the molecular mechanisms and the discovery of genetic risk factors common to both diseases and their implication in the development of new therapeutic targets.

Keywords : Diabetes; ischemic heart disease; genetics.

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