Resumen

VARGAS, César et al. Low HDL level is a predictor of Post Operative Atrial fibrillation and mortality after coronary artery bypass surgery. Rev Chil Cardiol [online]. 2015, vol.34, n.2, pp.106-112. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602015000200004.

Background: Low C-HDL level has been associated to an increased incidence of atrial fibrillation (AF) and cardiovascular mortality. Previously, we have observed that low C-HDL had the same type of association with post operative AF (POAF) and mortality following surgery for coronary artery disease. Aim: to evaluate whether a low C-HDL level is a predictor of POAF and mortality following revascularization surgery in a controlled study. Method: A prospective observational study included 100 consecutive patients undergoing revascularization surgery for stable coronary artery disease (CAD) in sinus rhythm and no prior AF. POAF was defined as AF sustained for more than 5 min or the occurrence of 5 or more episodes of AF extending for more than 5 seconds during the first 5 post operative days. A value <30 mg/dl was considered low C-HDL. Patients were followed for one year. Uni and multivariate analysis were used to identify predictors of POAF and mortality. Results: 31 patients developed POAF. A significant (p=0.017) OR of 5.01 (95% CI 1.3 - 18.8) between low C-HDL and POAF was shown. A similar association linked low serum albumin level to POAF (OR 6.4, C.I. 1.6 - 26). After 14.1 ± 1.7 months of follow-up global mortality was 6%. Low C-HDL turned out to be a significant predictor of mortality (H.R. 11.1, C.I. 1.1 - 38.4, p=0.04). Conclusion: Low C-HDL is an independent predictor of POAF and mortality after coronary artery revascularization surgery.

Palabras clave : coronary artery; bypass surgery; atrial fibrillation; HDL cholesterol; mortality.

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