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Revista de otorrinolaringología y cirugía de cabeza y cuello

versão On-line ISSN 0718-4816

Resumo

VALDES P, Constanza et al. Urinary leukotrienes in pediatric patients with sleep disordered breathing secondary to adenotonsillar hypertrophy. Rev. Otorrinolaringol. Cir. Cabeza Cuello [online]. 2019, vol.79, n.2, pp.151-158. ISSN 0718-4816.  http://dx.doi.org/10.4067/s0718-48162019000200151.

Introduction:

Sleep disorder breathing (SDB) affects 2%-3% of the pediatric population, being adenotonsillar hyperplasia (ATH) its main cause. An increase in the levels of urinary leukotrienes (ULT) has been measured in these patients, which could be correlated with the severity of the disease.

Aim:

To determine the level of ULT in children with SDB and ATH before and after adenotonsillectomy, and healthy controls. To correlate the levels of ULT with symptoms of SDB.

Material and method:

prospective study. SDB and ATH patients (n =12) and healthy controls (n =12) were included. The concentration of ULT in both groups was determined, before surgery and after a month of surgery.

Results:

There were no differences in the levels of ULT before and after tonsillectomy in the studied group. There were also no differences between the control group and the SDB group. No association was observed between the level of ULT and the severity of respiratory symptoms.

Conclusions:

ULT are not elevated in patients with SDB and ATH and they do not decrease after adenotonsillectomy. ULT are not correlated with the severity of the symptoms of SDB. The measurement of ULT would not be a useful tool in the evaluation of patients with SDB. New studies are needed to assess the role of the role of leukotrienes in this disease.

Palavras-chave : Adenotonsillectomy; adenotonsillar hyperplasia; sleep disorder breathing; leukotrienes; urinary leukotrienes; pediatric population.

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