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Revista de otorrinolaringología y cirugía de cabeza y cuello

versión On-line ISSN 0718-4816

Resumen

TORRENTE A, Mariela; PAREDES W, Alejandro; GAJARDO O, Pilar  y  ARREGUI V, Rodrigo. Cyclooxigenase-2 expression in laryngeal carcinoma. Rev. Otorrinolaringol. Cir. Cabeza Cuello [online]. 2014, vol.74, n.1, pp.07-11. ISSN 0718-4816.  http://dx.doi.org/10.4067/S0718-48162014000100002.

Introduction: Survival of laryngeal squamous cell carcinoma has not improved significantly in the last 20 years. Cyclooxigenase 2 (COX-2) has a role in carcinogenesis since it induces proliferation and angiogenesis, and inhibits apoptosis. Aim: To evaluate the expression of COX-2 in samples of laryngeal carcinoma. Material and methods: Patients attending Hospital San Juan de Dios and Barros Luco-Trudeau with diagnose of laryngeal carcinoma between 2008 and 2011 were included. Formalin fixed paraffin embedded samples were collected and COX-2 expression was assayed with immunohistochemistry. The study was approved by the ethics committee of Facultad de Medicina Universidad de Chile, and all patients consented. Results: 32 cases were included. COX-2 was overexpressed in 17, that is 53%. No correlation was identified with age, sex, or smoking habit. Conclusion: COX-2 overexpression is a frequent phenomenon in laryngeal carcinoma.

Palabras clave : Cyclooxigenase-2; carcinoma; larynx.

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