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Revista chilena de cirugía

On-line version ISSN 0718-4026

Abstract

DROPPELMANN M, Nicolás et al. New systemic therapies for melanoma. Rev Chil Cir [online]. 2016, vol.68, n.1, pp.81-86. ISSN 0718-4026.  http://dx.doi.org/10.4067/S0718-40262016000100015.

Abstract Melanoma represents a disease with high tendency to metastasize locally, regionally to the lymph nodes, and systemically to lungs, liver, brain and bone. The surgical treatment has been the cornerstone to treat melanoma patients, with excellent results in early stage, but with poor effectiveness in advance disease with systemic metastases. Traditional chemotherapy with cytotoxic agents has shown little impact on stage IV patients, which has motivated new investigation and innovation in this field. During last 4 years, FDA has approved new therapies for the treatment of metastatic or unresectable melanoma, mostly based in immunotherapy and signal transduction inhibitors, with very promising results. The surgeons treating these patients must be updated about these new therapies, which represent a new treatment opportunity for our patients.

Keywords : Melanoma; metastatic; immunotherapy; chemotherapy; treatment; new advances.

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