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Revista chilena de cirugía

On-line version ISSN 0718-4026


SANZANA S, EDGARDO. Evaluation of a phosphocalcic cement as bone substitute in vivo in rabbits. Rev Chil Cir [online]. 2006, vol.58, n.6, pp.431-440. ISSN 0718-4026.

Background: The best bone substitute is the same bone, obtained as bone autografts o allografts. However, its limited availability, promoted the development of diverse ceramic biomaterials, as phosphocalcic cements, that are potentially useful for bone substitution. Aim: To evaluate the in vivo behaviour of a tricalcium phosphate cement (CFT), as compared with coralline hidroxyapatite (HAC) and cancellous bone autograft (AOE). Material and methods: A 6 mm diameter bone cavity was made in the right distal femoral metaphyses of 36 New Zealand white rabbits. The animals were divided in 3 groups of 12 rabbits each, that were implanted with a tricalcium phosphate cement (CFT), coralline hidroxyapatite (HAC) or cancellous bone autograft (AOE), respectively. The results were obtained at 4 and 12 weeks with radiological, histological and histomorphometric studies. Results: The radiological and histological studies demonstrated a correct osseointegration and substitution of the 3 implants by new bone. The histomorphometric study showed that bone neoformation obtained at 4 and 12 weeks was greater, with statistically significant differences, in CFT and AOE groups, being equivalent between these 2 groups. At 4 and 12 weeks, the resorption in the CFT group was significant higher than in the HAC group, (p<0.05). Conclusions: CFT is a osteoconductive, osteotransductive and biocompatible material that behaves as a bone substitute in femoral defects of experimental animals

Keywords : Bone graft; tricalcium phosphate cement; coralline hidroxyapatite.

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