Abstract

ASTROZA E, GASTÓN; GONZALEZ P, MIGUEL; PALADINES Z, PABLO  and  CASAS C, RAÚL. Concordance between intraoperative frozen section and deferred biopsy for the diagnosis of malignant thyroid lesions. Rev Chil Cir [online]. 2006, vol.58, n.6, pp.410-413. ISSN 0718-4026.  http://dx.doi.org/10.4067/S0718-40262006000600004.

Background: Intraoperative frozen section s essential procedure during thyroidectomy, to decide magnitude of the excision. There is usually a good concordance between fast and deferred biopsy results in hands of experimented pathologists. Aim: To assess the concordance between fast and deferred thyroid biopsies. Material and methods: Prospective study of 351 thyroidectomies, performed to 312 women and 39 men, aged 13 to 83 years, in which a fast and a deferred biopsy, were performed. Results: Intraoperative frozen section diagnosed a total of 88 malignant lesions, that were confirmed with the deferred biopsy in 75 cases (85.2%). In 13 (14.8%) patients with a malignant lesion diagnosed with the fast biopsy, the final result was benign. In 263 cases, the fast biopsy reported a benign lesion, that was corroborated with the deferred biopsy in 238 patients (90,5%). In 25 of these patients (9.5%), the deferred biopsy showed a malignant lesion. Therefore, the sensitivity and specificity of the fast biopsy were 75 and 95%, respectively. Papillary carcinoma was the most common pathological finding in 15 of 25cases. Conclusions: intraoperative frozen section thyroid has a high specificity for the diagnosis of malignant lesions, but sensitivity must be improved

Keywords : Intraoperative frozen section; thyroid cancer; thyroidectomy.

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