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International journal of odontostomatology

On-line version ISSN 0718-381X


ALARCON-ARRATIA, Ana; MUNOZ-REPETTO, Maximiliano; SCHNETTLER, Katty  and  ULLOA-MARIN, Carolina. Peripheral Giant Cell Granuloma and Hyperparathyroidism. Case Report. Int. J. Odontostomat. [online]. 2019, vol.13, n.3, pp.266-270. ISSN 0718-381X.

A 31-year-old female patient with chronic renal insufficiency in hemodialysis and secondary hypertension consulted due to an enlarging intraoral lesion in relation to the left marginal vestibular gingival, with 6 months of evolution. A 15mm mass in relation to mandibular left molars was noted. Radiograph showed periodontal involvement of mandibular left second molar. Excisional biopsy and tooth 3.7 extraction were performed. Histopathology reported a peripheral giant cell granuloma. Laboratory tests were requested for suspected hyperparathyroidism (aiding in the diagnosis) (high PTH, normal phosphatemia and calcemia). Evolution was favorable, without signs of reappearance after 3 months. The histopathological diagnosis of giant cell lesions should be complemented with clinical, laboratory and imaging tests. The final objective is to make the differential diagnosis between brown tumor, central giant cell granuloma and peripheral giant cell granuloma because the treatment varies considerably. There are few reports in the literature about the association between peripheral giant cell granuloma and hyperparathyroidism. This case corresponds to peripheral giant cell granuloma, possibly associated with parathormone hypersecretion.

Keywords : granuloma; giant cell; hyperparathyroidism secondary; chronic kidney failure.

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