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International journal of odontostomatology

On-line version ISSN 0718-381X

Abstract

CASTRO-ORTEGA, Adrian; MUELA-CAMPOS, Daniela; SOTO-BARRERAS, Uriel  and  BOLOGNA-MOLINA, Ronell. Immunohistochemical Expression of Ki-67 in Central Giant Cell Lesion. Int. J. Odontostomat. [online]. 2019, vol.13, n.2, pp.150-156. ISSN 0718-381X.  http://dx.doi.org/10.4067/S0718-381X2019000200150.

The central giant cell lesion (CGCL) is a benign osteolytic lesion which in some cases presents an aggressive behavior with recurrence and poor prognosis. Ki67 is a nuclear protein whose general function is the regulation of cell proliferation. This marker is used to identify proliferating cells and as a prognostic tool in the diagnosis of neoplasms. The aim of this study was to quantify the immune expression of Ki-67 in the different cell populations of CGCL and analyze its association with clinical, demographic and radiographic characteristics. The Ki-67 immune expression of 17 cases of LCCG was evaluated in two cell populations: multinucleated giant cells (CGM) and stromal mesenchymal cells (SMC). The statistical analysis was carried out with SAS 9.0 and SPSS version 23.0, with an alpha tax level of P <0.05. The CME showed average immune expression of 9.4 % and the CGM of 0.65 %. No statistically significant relationship was found between the clinical, demographic and radiographic characteristics of the CGCL and the immune expression of Ki-67. The expression of Ki-67 in CME suggests that this population is in constant cellular activity, and that the CGCL are dynamic lesions in a continuous differentiation process.

Keywords : immunoexpression; Ki-67; central giant cell lesion; cell proliferation.

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