SciELO - Scientific Electronic Library Online

 
vol.13 issue2Bacterial Adhesion in Black Silk Suture Thread and Nylon Post Simple Dental Extraction: Controlled Clinical TrialCross-Sectional Study of Mandibular Canal Branching in Regions Affected by Dental Inflammation with Cone Beam Computed Tomography author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


International journal of odontostomatology

On-line version ISSN 0718-381X

Abstract

MORO, Cecilia; AGUZZI, Alejandra  and  VIRGA, Carolina. Effect of Vitamin E and Alendronate on Mineral Density in Rat Maxillary Bone. Int. J. Odontostomat. [online]. 2019, vol.13, n.2, pp.137-141. ISSN 0718-381X.  http://dx.doi.org/10.4067/S0718-381X2019000200137.

The bone balance is mediated by an immunoendocrine regulation, this being a complex process. A number of pharmacotherapies are used among the actions taken to maintain the density and structure of the skeleton. Several studies have shown that both Alendronate (AL) and Vitamin E (E) contribute to the inhibition of bone resorption. Objective: To study the effect of combined administration of (LA) subcutaneously and (E) was administered three times per week also subcutaneously with a dosage of 20 mg / kg body weight. The pharmaceutical formulation was 0.5 mg / kg body weight for AL and 20 mg / kg vitamin E. The effect was evaluated in male Wistar rats (n = 108), 90 ± 20 g, divided into 4 groups. Extraction of the first lower molars was performed. The drug was injected subcutaneously at time 0, 7, 15 and 30 days post-surgery. The images of the jaws were acquired by radiovisiography, at each experimental time and were analyzed with Image ProPlus Software version 4.1 of Media Cibernetics. Statistical studies: non-parametric: Kruskal-Wallis test Group C (which recorded the lowest mean intensity) was significantly different from the E and AE groups (p <0.001), but not from the group that used only Al (P = 0.070, p> 0.05). The Al, E and combined Al-E groups did not differ significantly from each other (p> 0.05 in all cases). The data evaluated serve to show a favorable trend in relation to the beneficial effect of the combination of AL and vitamin E.

Keywords : bisphosphonates; vitamin E; bone remodeling.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )