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International journal of odontostomatology

On-line version ISSN 0718-381X

Abstract

CARREON-BURCIAGA, R. G et al. Expression of E-Cadherin and Syndecan-1 in Oral and Skin Lichen Planus. Int. J. Odontostomat. [online]. 2014, vol.8, n.3, pp.439-445. ISSN 0718-381X.  http://dx.doi.org/10.4067/S0718-381X2014000300019.

Lichen planus is an immunological lesion is characterized by basal keratinocytes apoptosis, liquefaction of the basal membrane and linphoplasmocitary infiltration, these features may be associated with loss of cellular adhesion and risk of malignant transformation. To identify the regulatory potential associated with cell adhesion of basal keratinocytes and the malignant transformation potential, the "in situ" expression of E-cadherin and Syndecan-1 proteins in skin and oral lichen planus were investigated. A total of 37 cases of skin lichen planus and 5 cases of oral lichen planus we reevaluated by immunohistochemical approach, using E-cadherin and Syndecan-1antibodies. In areas of active disease in skin lichen planus the basal keratinocytes did not express E-cadherin and Syndecan-1 expression was focal, in the of epithelial tissue areas of free lesion the expression of both proteins were similar. Changes in E-cadherin and Syndecan-1 expression suggest a possible association of this proteins with the pathogenesis of skin and oral lichen planus.

Keywords : lichen planus; E-Cadherin; Syndecan-1; malignant transformation.

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