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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

RAMIREZ-TAGLE, Rodrigo et al. SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE. J. Chil. Chem. Soc. [online]. 2021, vol.66, n.1, pp.5063-5066. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072021000105063.

A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

Palabras clave : Amlodipine; Chitosan; Nanocomposite; Drug-release properties; Docking studies.

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