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vol.62 número1SYNTHESIS, SPECTRAL ANALYSIS AND ANTIBACTERIAL EVALUATION OF 5-SUBSTITUTED-1,3,4-OXADIAZOL-2-YL 4-(4-METHYLPIPERIDIN-1-YLSULFONYL)BENZYL SULFIDESTWO NOVEL TCPP PORPHYRINIC COMPOUNDS: IN SITU SYNTHESES, CHARACTERIZATION AND REACTION MECHANISM índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

BENGHANEM, SAIDA et al. EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS. J. Chil. Chem. Soc. [online]. 2017, vol.62, n.1, pp.3376-3380. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072017000100014.

Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in distilled water at 25°C and biological activities have been investigated. CC1 hydrogel revealed higher potential swelling than CC2. Hydrogels showed to possess an important antioxidant activity equal to 66.67% for CC1 and 57.27% for CC2, to scavenge hydroxyl radicals at 2mg/mL. And the values of their reducing power were approximately 53% and 57%. From the hemolytic potential test the obtained materials were hemo-compatible. The anti-inflammatory activity exhibited that hydrogels were able to protect albumin from denaturation.

Palavras-chave : Chitosan; Carboxymethylcellulose; Hydrogels; Swelling; Biological activities.

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