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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

CHOVATIYA, YOGITA L; KUNDALIYA, KAUSHIK N; GIRI, RAKESH R  y  BRAHMBHATT, DINKER I. SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW ASYMMETRICALLY SUBSTITUTED 4-ARYL- 2,6-DI(COUMARINYL) PYRIDINES. J. Chil. Chem. Soc. [online]. 2016, vol.61, n.1, pp.2788-2791. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072016000100009.

In the present work the synthesis of various 4-aryl-2-(coumarin-3-yl)-6-(4-methyl-3-phenyl coumarin-6-yl)pyridines (6a-i) and 4-aryl-2-(coumarin-3-yl)-6-(4-methyl-7-methoxy coumarin-8-yl)pyridines (7a-i) have been carried out by reacting 1-[2(H)-1-benzopyran-3-yl]-3-aryl-prop-2-en-1-ones (coumarinoyl chalcones) (3a-f) with appropriate coumarinoyl methyl pyridinium bromide salt 4 and 5 respectively. The target compounds were characterized by the IR,JH-NMR, 13C-APT and mass spectral analysis. Preliminary examination of target compounds as antimicrobial agents has been carried out using Broth dilutionmethod.

Palabras clave : Keywords: Dicoumarinyl pyridines; Krohnke's reaction; antimicrobial activity; Broth dilution method.

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