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vol.57 número4SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASESMODEL-BASED QUANTUM-CHEMICAL STUDY OF THE UPTAKE OF SOME POLYCHLORINATED POLLUTANT COMPOUNDS BY ZUCCHINI SUBSPECIES índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

ZAHEER, MUHAMMAD et al. MICROWAVE ASSISTED SYNTHESIS OF BIOLOGICALLY ACTIVE 4-HYDROXY-7V-(PHENYLCARBONYL)-2H-1,2-BENZOTHIAZINE-3-CARBOHYDRAZIDE 1,1-DIOXIDE DERIVATIVES. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.4, pp.1492-1496. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072012000400031.

Microwave assisted synthesis of a series of 4-hydroxy-N'-(phenylcarbonyl)-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides from sodium saccharin is reported. Sodium o-benzosulfimide was N-alkylated with ethyl chloroacetate followed by base catalyzed ring expansion to six membered 1,2-benzothiazine through Gabriel-Coleman type rearrangement yielding ethyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide. It was later condensed with a series of benzohydrazides synthesized from various carboxylic acids to get the title compounds. All the synthesized compounds were subjected to preliminary evaluation for their biological activity against series of Gram positive, Gram negative bacteria and fungi. Some of the compounds showed marked activity against the selected microorganisms.

Palavras-chave : Microwaves; Benzohydrazide; Carbohydrazides; 1,2-Benzothiazine; Anti-bacterial; Anti-fungal.

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