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Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

MISHRA, RAVINESH et al. SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.4, pp.856-859. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000400006.

Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.

Keywords : Pyridazine; Antihypertensive activity; Non invasive tail-cuff method.

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