SciELO - Scientific Electronic Library Online

 
vol.38 número2Análisis 3-D de la Vía Aerea Relacionado con la Morfología FacialLocalización de los Centros de las Regiones Densas del Nervio Intramuscular de los Músculos del Manguito Rotador: Una Guía para la Inyección de Toxina Botulínica A por Espasticidad con Dolor de Hombro índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

CAVUS, Yunus  y  DEGER, Ugur. Investigation of ADAMTS-1, BAX and IL-10 Expressions in Granulosa Cells Determinanting Fertilization Success in IVF. Int. J. Morphol. [online]. 2020, vol.38, n.2, pp.427-434. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022020000200427.

Granulosa cells (GCs) are essential components of follicles and play a role in regulating follicle development. The aim of this study was to investigate certain cellular components involved in the proliferation, differentiation and functional characteristics of granulosa cells in the success of fertilization of human oocytes during invitro fertilization (IVF) via immunohistochemical techniques. In this study, 30 patients who were diagnosed as primary or secondary infertility, polycystic ovary syndrome in the IVF center of Memorial Hospital, Department of Obstetrics and Gynecology were included. The amount of Anti Müllerian Hormone (AMH) in blood and granulosa cell diameter and cell core diameter were measured in 20 cells collected from each patient. In addition, degeneration scoring and BAX, ADAMTS-1, IL-10 expressions in granulosa cells were evaluated (p <0.01). It was thought that apoptosis induced by human GCs might be an indicator of egg quality. Moderate expression of ADAMTS-1 was thought to be related to failure of ovulation, deterioration of oocyte quality and decreased fertilization rate. This decrease in AMH levels may be associated with defects in granulosa cells. Therefore, significantly lower AMH secretion and increase in IL10 expression levels in healthy people can be explained by the increase of granulocyte cells.

Palabras clave : Granulosa Cells: Fertility: ADAMTS-1; IL-10: BAX: immunohistochemistry.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )