SciELO - Scientific Electronic Library Online

 
vol.38 número2El Entrenamiento Multimodal es más Eficiente que el Entrenamiento Continuo Moderado para el Manejo de la Composición Corporal, El Perfil de Lípidos y el Metabolismo de la Glucosa en Adultos Mayores DiabéticosCaracterísticas Morfológicas de los Abscesos Hepáticos Según su Etiología índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

LIAO, Libin; YAO, Xueping; HUANG, Jufang  y  BAI, Shengbin. Prenatal Stress Up-Regulated Hippocampal Glucocorticoid Receptor Expression in Female Adult Rat Offspring. Int. J. Morphol. [online]. 2020, vol.38, n.2, pp.400-405. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022020000200400.

Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. Glucocorticoid receptor (GR) is an important target of glucocorticoid. Therefore the aim of the present study was to investigate the expression of GR in prenatally stressed adult offspring and the relationship between GR expression and behavior in offspring. Pregnant rats received restraint stress during the last week of pregnancy. Hippocampal glucocorticoid receptor expression levels in the offspring were detected on postnatal 60 (P60).Cognition function was also detected. It shows significantly lower hippocampal GR expression was observed in female prenatally stressed offspring compared with their controls at P60. Corresponding to the expression of GR, female prenatally stressed offspring exhibited poorer spatial learning and memory abilities in the Barnes maze than control, This suggests that cognitive impairment in prenatally stressed rat offspring attribute lower hippocampal GR expression.

Palabras clave : Prenatal stress; Cognitive impairment; Glucocorticoid receptor; Hippocampus.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )