SciELO - Scientific Electronic Library Online

 
vol.38 número2Descripción Anatómica de la Arteria Polar Renal Accesoria y su Relación con la Hipertensión ArterialRecomendaciones para Mejorar la Calidad de las Fotos en Fotogrametría de Corto Alcance, Ejemplificado en Huesos de las Manos de Chimpancés y Gorillas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

AL-DOAISS, Amin Abdullah  y  AL-SHEHRI, Mohammed Ali. Protective Effect of Gum Arabic/Insulin Against Histological Changes in Testes of Diabetic Rats. Int. J. Morphol. [online]. 2020, vol.38, n.2, pp.340-347. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022020000200340.

Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic rats have not been enough investigated. This study was designed to investigate histological changes in testes of male Wistar rats and investigate the protective potential of GA against diabetes- induced testicular toxicity in rats. Fifty adult male Wistar rats were assigned into five groups (n = 10 of each): Group 1 (non-diabetic rats) served as control, Group 2 served as diabetic group injected with Alloxan, Group 3 diabetic group plus insulin, Group 4 diabetic group given 15 % GA in drinking water and Group 5 diabetic group plus insulin and GA for 4 weeks. Compared to control group, histopathological examinations of testicular tissue from the diabetic rats group, showed degeneration, necrosis and atrophy of seminiferous with presence of giant cells. Necrosis and hemorrhage in the renal tissue. On the other hand, treatment with GA ameliorated all the previous histological changes. Overall, oral administration of GA alone or with insulin daily for 4 weeks successfully ameliorated the testicular histological changes. These data demonstrated that GA significantly improved diabetes complication in rat testis. This study suggested that GA might have a protective effect against oxidative stress-induced impaired testicular functions in diabetic rats. The possible mechanisms of this action might be ascribed to their antioxidant and anti-inflammatory properties.

Palabras clave : Diabetes mellitus; Testes; Gum Arabic; Histology; Rat.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )