SciELO - Scientific Electronic Library Online

vol.37 issue4Development of a Sheet Plastination Protocol with Polyester Resin Applied to Human Brain SlicesEffects of Ketoprofen in Spermatogenesis of Mice Exposed to Continuos Hypobaric Hypoxia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


International Journal of Morphology

On-line version ISSN 0717-9502


OCAMPO, Juan; OLATE, Sergio; HAIDAR, Ziyad S  and  VASQUEZ, Bélgica. Hyposialia and Xerostomy Post Irradiation: Innovative Therapies in the Biomolecular Field. Int. J. Morphol. [online]. 2019, vol.37, n.4, pp.1564-1571. ISSN 0717-9502.

Human salivary glands can be seriously injured by the radiotherapy used against head and neck neoplasms, producing hyposialia and xerostomy, which affect oral and systemic health, diminishing the person’s quality of life. Current conventional treatments are designed to reduce symptoms, without acting on the pathophysiological changes that occur at the glandular level. This review attempts to analyze those preventive and /or curative therapies that are developing in the biomolecular field and that have a promising future due to their innovative features: Gene therapy, stem cell therapy and growth factor therapy. An additional contribution of nanotechnology is evident, which is improving the routes of treatment application.

Keywords : Hyposialia; Xerostomy; Salivary glands; Irradiation; Gene therapy; Stem Cells; Growth Factors.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )