SciELO - Scientific Electronic Library Online

 
vol.36 issue2CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and PapainThe Sagittal Otolith Morphology Observations of Sturgeon Species in Iranian Waters of the Caspian Sea author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

SHIKHBAHAEI, Fatemeh; GHANBARI, Ali  and  KESHTMAND, Zahra. Therapeutic Effect of Thymoquinone Against Methotrexate- Induced Damage on Sperm Parameters in Mice. Int. J. Morphol. [online]. 2018, vol.36, n.2, pp.519-522. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022018000200519.

Methotrexate drug is commonly used to treat cancer; it is known to cause reproductive damage. Thymoquinone, as a natural component of herbs has many healthy benefits shown in researches. The present study aimed to investigate probable therapeutic effects of Thymoquinone against Methotrexate-induced damage on sperm parameters in mice. In this experimental study, 30 male mice (25-30 g) were divided into five groups of six in each group. The mice were received normal saline (control group), Methotrexate (20 mg/kg), Methotrexate (20 mg/kg) + Thymoquinone (2, 10 and 20 mg/kg) by intraperitoneal injection. On the day after the last injection, the sperm parameters including motility, viability and count of sperms were assessed. Data analysis was performed using one-way ANOVA followed by Tukey test. Methotrexate alone showed a significant reduction in sperm parameters compared to the control group (P=0.00). In groups treated with Methotrexate and Thymoquinone, sperm parameters (motility ,viability, count sperm) did not show any significant differences with control group (P=0.00). Thymoquinone, as a potent antioxidant, could compensate for the toxicity induced by Methotrexate. These medical trends may be useful for diminishing the side effects of Methotrexate on the male reproductive system.

Keywords : Thymoquinone; Methotrexate; Sperm; Mice.

        · abstract in Spanish     · text in English     · English ( pdf )