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International Journal of Morphology

On-line version ISSN 0717-9502


SCHENCKE, Carolina; SALVO, Jessica; VASCONCELLOS, Adriana  and  DEL SOL, Mariano. Comparative Study of Healing in Burns Treatment Based on Ulmo Honey (Eucryphia cordifolia) and Oral Vitamin C in Guinea Pig (Cavia porcellus) versus Hydrogel. Int. J. Morphol. [online]. 2013, vol.31, n.3, pp.839-844. ISSN 0717-9502.

A burn is a traumatic injury resulting in local and systemic injury with oxidative changes. Honey has antioxidant, anti-inflammatory and antibacterial properties. At the same time, among other benefits vitamin C improves the epidermal barrier and reduces wound contraction. The aim of this study was to evaluate morphologically the effect of regimen with Ulmo honey + vitamin C in guinea pigs and compare its healing and debriding potential with Hydrogel + tull in injuries caused by type B burns at day 10 post-injury. We used 15 guinea pigs (Cavia porcellus) distributed in groups A (Ulmo honey and vitamin C topical, oral), B (hydrogel-tull), and control (0.9% saline). Wound debridement was observed daily and wound treatment was performed daily until biopsies were obtained at day 10 post-injury. Four 4 um sections were stained with HE, Masson's trichrome and PAS. In group A there was rapid debridement when compared with groups B and Control. Treatment study presented advanced proliferative phase at day 10 post-injury with vascularized tissue, and presence of collagen fibers and fibroblasts. The epidermis was completely regenerated, presenting a visible basal lamina by PAS staining. Group B presented an initial proliferative fibroblastic phase, showing acute dermal elements. Epithelialization phase was completed in only 50% of the samples. Ulmo honey + vitamin C substances have been shown to be effective as treatment material in healing of type B burns in guinea pig skin.

Keywords : Healing; Honey; Vitamin C; Burns.

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