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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

ZEHRA, Uruj; TAHIR, Mohammad; JAFFERY, Fahim H  and  LONE, Khalid P. Ginkgo biloba Effects on Mice Fetal Liver. Int. J. Morphol. [online]. 2010, vol.28, n.3, pp.765-770. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022010000300017.

Ginkgo biloba is considered to be an alternative drug for various indications; unfortunately very few studies are available on its side effects. This present study describes the harmful effects of Ginkgo biloba on developing fetal liver. Two experimental groups of six pregnant female mice each were given Ginkgo biloba at human therapeutic dose (A) and a higher dose (B) throughout the gestation period. A third group (C) was taken as a control and given distilled water only. Fetal livers were examined and the effects of the drug observed. There were signs of congestion and fatty change along with dilatation of sinusoids in a dose dependent manner concluding that Ginkgo biloba affects fetal liver.

Keywords : Ginkgo biloba; Fetal liver; Congestion; Fatty change; Histology.

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