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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

DAVARIAN, Ali; KHORI, Vahid  and  NAYEBPOUR, Mohsen. Cardioprotective Effects of Exogenous and Endogenous Hydrocortisone in the Rabbit Model of Ischemia-Reperfusion. Int. J. Morphol. [online]. 2010, vol.28, n.3, pp.653-658. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022010000300001.

Reducing the infarct size in acute myocardial infarction is one of the most important goals driving new drug research and development. During the last two decades, many clinical studies have found cardioprotective effects of corticosteroids, but their exact role in ischemic preconditioning remains questionable. The aim of the present study was to determine the protective effects of hydrocortisone sodium succinate on myocardial preconditioning in rabbit hearts. Twenty-four male New Zealand rabbits were divided randomly & equally in four groups: 1) control, 2) Infarct, 3) Ischemic preconditioning (IP) and 4) Hydrocortisone (HYD). The HYD group received 50mg/kg Hydrocortisone 45min before major ischemia. Serum levels of cardiac troponin-T(cTNT) and cortisole were measured before and after the protocols. Triphenyl-tetrazolium chloride staining was used to determine the infarcted area. In the present study, exogenous hydrocortisone decreased infarct size by 53% in comparison to the infarct group. Serum level of cortisole was increased in the IP and HYD groups, and was significant in the HYD group (p<0.01). An increasing trend in cortisole level was associated with a decreasing trend in infarct size and cTNT in the IP and HYD groups (p>0.01). In conclusion, we showed that hydrocortisone has cardioprotective effects when injected before the onset of myocardial infarction. In addition, we have proposed for the first time that endogenous hydrocortisone may play a role in ischemic preconditioning phenomena.

Keywords : Hydrocortisone; Infarct size; Ischemia-reperfusion model; Ischemic preconditioning; Serum cortisole.

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