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International Journal of Morphology

On-line version ISSN 0717-9502


FONSECA, Ismael Bernardo et al. Inmunohistochemistry Expression of Vimentin, CD 34 and c-Kit (CD117) in Gastrointestinal Stromal Tumors. Int. J. Morphol. [online]. 2010, vol.28, n.2, pp.453-459. ISSN 0717-9502.

GIST´s are tumors of mesenchymal origin that were previously classified as smooth muscle tumors despite the advances in the field of electron microscopy and immunohistochemistry have allowed their differentiation. They derive from interstitial cells of Cajal. They account for 1-2% of all cancers of the digestive tract. They are more common in people over 40 years of age, with equal incidence in both sexes. We studied 30 cases of gastrointestinal stromal tumors in a prospective and retrospective analysis in the period between 1987 and 2007. For retrospective material were studied in paraffin tissue blocks. They were fixed in formaldehyde to 10% and included in paraffin by routine staining with H&E and histochemical techniques (PAS and Masson trichrome). We performed further, immunohistochemical de panel: Vimentin, smooth muscle actin, CD-34 and c-Kit (CD-117). To study the pathological features in relation to the clinical symptoms presented by GIST´s, we observed the behavior of the same taking into account different variables. With regard to immunohistochemistry, vimentin was positive in 100% of the cases, whereas CD-34 and CD-117 were positive in approximately 90%. The tendency of these tumors follow an indolent clinical course with late recurrence risk, does recommend monitoring patients regularly and for an indefinite period. The rarity of this disease, having had the opportunity to study 30 cases of GISTs and analysis of the value of immunohistochemistry for the confirmation of the histogenesis object of the present communication.

Keywords : Immunohistochemistry; Stromal; Gastrointestinal; Interstitial; C-Kit.

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