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International Journal of Morphology

On-line version ISSN 0717-9502


FAZELI, Seyyed Amirhossein et al. Resistance of CA1 Pyramidal Cells to STZ-Induced Diabetes in Young Rats. Int. J. Morphol. [online]. 2009, vol.27, n.4, pp.997-1001. ISSN 0717-9502.

The pyramidal cell density of CA1 hippocampal subfield following STZ-induced diabetes in young rats were studied. 12 male albino 6-week Wistar rats were allocated equally in groups of normal and diabetic. Hyperglycemia induced by Streptozotocin (80 mg/kg) in animals of diabetic group. After 5 weeks of study, all the rats were sacrificed and coronal sections were taken from dorsal hippocampal formation of the right cerebral hemispheres and stained with crysel violet. The area densities of the CA1 pyramidal cells were measured and compared among two groups. No significant difference between the densities of two experimental groups was found. The results can arise from the short period of diabetes and also the possible regenerative processes in developing brain of the young diabetic rats which compensated significant diabetes-induced neuronal loss.

Keywords : Pyramidal cell density; CA1; Hippocampus; Diabetes; Rat.

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