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International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

PEDRAZZI, Vinícius et al. In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive. Int. J. Morphol. [online]. 2009, vol.27, n.3, pp.801-803. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022009000300026.

The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium stearate (HPMC/Cp/StMg) was developed having the sodium fluoride as active principle. This kind of system was evaluated according to its resistance to the removal by means of physical test of tensile strength. Swine buccal mucosa extracted immediately after animals' sacrifice was employed as substrate for the physical trials, to obtain 16 test bodies. Artificial saliva with or without mucin was used to involve the substrate/bioadhesive system sets during the trials. Artificial salivas viscosity was determined by means of Brookfield viscometer, showing the artificial saliva with mucin 10.0 cP, and the artificial saliva without mucin 7.5 cP. The tensile strength assays showed the following averages: for the group "artificial saliva with mucin" - 12.89 Pa, and for the group "without mucin" - 12.35 Pa. Statistical analysis showed no significant difference between the assays for both artificial salivas, and it was possible to conclude that the variable mucin did not interfered with the bioadhesion process for the polymeric devices. The device was able to release fluoride in a safe, efficient and constant way up to 8 hours.

Palabras clave : Drug delivery systems; Oral delivery; Mucin; Oral mucosa; Fluoride.

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