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International Journal of Morphology

On-line version ISSN 0717-9502


ZAFAR, Muhammad; NAEEM-UL-HASSAN NAQVI, Syed; AHMED, Masood  and  KAIMKHANI, Zahid Ali. Altered Kidney Morphology and Enzymes in Streptozotocin Induced Diabetic Rats. Int. J. Morphol. [online]. 2009, vol.27, n.3, pp.783-790. ISSN 0717-9502.

We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology, anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) in albino rats. The aim of the study was to investigate the association between diabetic kidney complications and kidney enzyme alterations. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians & Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty (80) albino rats were divided into five groups: control (A) and STZ treated (B, C, D, and E) which were sacrificed 2, 4, 6 and 8 weeks post treatment respectively. Histopathology of kidney showed lesions similar to human glomerulosclerosis, glomerular membrane thickening, arteriolar hyalinization and tubular necrosis. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and pseudocholinesterase (PChE) were observed in the kidney. It seems that the diabetic complications in the kidney are likely to be associated with alterations in enzyme levels.

Keywords : Streptozotocin; Aminotransferases; Alkaline phosphatase; Pseudocholinesterase; STZ-diabetes; Rats.

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