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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

GORDON-NUNEZ, Manuel Antonio et al. Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas. Int. J. Morphol. [online]. 2008, vol.26, n.3, pp.567-572. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022008000300010.

The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas.onineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies againstp53, PCNA and bcl-2 proteins. It was observedweak labeling for p53 in 12 cases (63.1%) andforPCNA in 8 (42.1%). With respect to the bcl-2 labeling index,ono expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably doesonot effectively particípate in the pathogenesis of this tumor.

Keywords : Pleomorphic adenoma; Salivary gland tumour; p53; PCNA; bcl-2.

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