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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

FLANK EJCHEL, Tatiana et al. ASSOCIATION OF CHROMOSOME X LOSS IN ELDERLY WOMEN WITH APOLIPOPROTEIN A-IV: 360 POLYMORPHISM. Int. J. Morphol. [online]. 2004, vol.22, n.2, pp.139-144. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022004000200007.

Chromosome X loss associated with advancing age in women is well stablished in cytogenetics. However, genetic factors involved in this chromosome loss or no disjunction are poorly understood. Apolipoproteins have been associated with chromosome syndromes, such as Trisomy 21 and 18 and their participation in chromosome segregation have been suggested. Apolipoprotein A-IV:360 polymorphism has been associated with cardiovascular diseases, in our population. Twenty four old women, aged 72 to 87 years old selected according to the presence or absence of allele 2 (HIS) were investigated in relation to chromosome X loss. Cytogenetic analysis was performed in interphase lymphocyte nuclei by means of FISH ( Fluorescence In Situ Hibridization) using X centromeric DNA probe. DNA was isolated from blood cells amplified by PCR and digested with Fnu4HI. A higher significant proportion of cells with X chromosome loss was observed in elderly women with allele 2 (HIS) .These results indicate the participation of apolipoprotein A-IV:360 polymorphism in chromosome segregation. The involved mechanisms could be related to oxidative damage related to microcirculation abnormalities and cell death. The biological role of apolipoprotein A-IV on chromosome segregation needs to be further investigated

Keywords : A.IV.360 polymorphism; Chromosome X lose; Citogenetics.

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