Resumen

MORALES, Inelia; ARATA, Loredana  y  MACCIONI, Ricardo B. Neuroinmmunomodulation in neurodegenerative diseases: new scientific evidence. Rev. chil. neuro-psiquiatr. [online]. 2015, vol.53, n.1, pp.53-58. ISSN 0717-9227.  http://dx.doi.org/10.4067/S0717-92272015000100007.

Microglial cells play a major role in the innate immunity of the central nervous system. Alterations in the normal cross-talks between microglia and brain neuronal cells may lead to serious disturbances and neurodegenerative diseases. We have postulated that neuroinflammatory processes are a critical factor triggering the pathological cascade leading to neuronal degeneration. In our neuroimmunomodulation theory, external or internal damage signals activate microglial cells, producing cytotoxic factors that induce neuronal degeneration. These factors activate protein-kinases, that lead to tau hyperphosphorylation, and its consequent oligomerization. The tau aggregates released into the extracellular medium favor a positive feedback mechanism that determines neurodegeneration. Nowadays, natural components with a string anti-inflammatory activity and that cross the blood brain barrier appears as candidates for prevention and treatment of degenerative brain disorders such as Alzheimers'disease.

Palabras clave : Neurodegenerative diseases; neuroimmunomodulation; glial cells; proinflammatory cytokines; tau protein; neuronal cells.

        · resumen en Español     · texto en Español     · Español ( pdf )