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Revista chilena de neuro-psiquiatría

versión On-line ISSN 0717-9227

Resumen

VENEGAS F, Pablo et al. Pyridoxine for drug induced dyskinesia: A placebo-controlled randomized cross-over trial. Rev. chil. neuro-psiquiatr. [online]. 2006, vol.44, n.1, pp.9-14. ISSN 0717-9227.  http://dx.doi.org/10.4067/S0717-92272006000100002.

Tardive Dyskinesia is a common and disabling adverse effect of drugs acting on Dopaminergic pathways. An important proportion of patients does not respond to the conventional treatment. In this study 28 severe and refractory patients from a Psychiatric Hospital were randomized in a cross over design to placebo and high doses (500 mg per day) of Pyridoxine for 4 weeks each one. The patients were evaluated using the Abnormal Involuntary Movement Scale (AIMS) at 2 and 4 weeks of each cycle. Pyridoxine was well tolerated, and no adverse effect occurred during the study. No statistical differences between Pyridoxine and Placebo were found. Surprisingly, in both groups equally good responses were found

Palabras clave : Drug Induced Dyskinesia; Pyridoxine; Drug therapy; randomized controlled trial; placebo.

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