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Revista chilena de neuro-psiquiatría

versión On-line ISSN 0717-9227


BEHAR, Rosa. Anorexigens: Indications and Interactions. Rev. chil. neuro-psiquiatr. [online]. 2002, vol.40, n.2, pp.21-36. ISSN 0717-9227.

Background. Although anorexigens are not widely used in psychiatry, psychiatrists frequently prescribe psychotropics to patients already being treated with appetite suppressants, involving significant interactions between them and other medications which may cause irreversible and even fatal complications. Aim. To describe the main anorexigen agents available in Chile along with their classifications, characteristics, pharmacokinetics, indications, contraindications, adverse effects and interactions. Material and methods. Current specialized literature on the subject is reviewed. Results. Appetite suppressants are just one component of integral treatment in obese patients with results improving when the patient's eating habits are modified. Anorexigens have a high potential for abuse, dependence, tolerance and deprivation syndrome. Their foremost side effects affect cardiovascular, gastrointestinal and central nervous systems. The most widely used in Chile between 1997 and 1998 were phentermine, diethylpropion, phenproporex and dexfenfluramine. Discussion. Anorexigens are generally prescribed to treat obesity. They must be used only under close medical supervision and are recommended for a short-term use. They have significant interactions with MAOIs, SSRIs, decongestants, antitussives, antihistamines, general anaesthetics, alcohol and illegal substances, and other drugs metabolised through cytocrome P450. The danger of serotoninergic syndrome is emphasized. Chile, Argentina and Brazil are among the countries with the highest rates of stimulants consumption

Palabras clave : anorexigens; indications; interactions.

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