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Revista chilena de neuro-psiquiatría

versión On-line ISSN 0717-9227


PASCUAL, Rodrigo. Cerebellar Impairment Induced by Early Social Isolation: A Morphological and Immunocytochemical Study. Rev. chil. neuro-psiquiatr. [online]. 2001, vol.39, n.1, pp.57-68. ISSN 0717-9227.

In the present study, we analyzed the effect of early adverse experiences on the morpho-functional development of the cerebellar cortex by using the social isolation model. One hundred and three Sprague-Dawley rats were divided in two experimental groups 18 days after birth: (a) a control group (SC; 3-4 animals per cage) and (b) an isolated group (IC). IC rats were maintained in small, individual compartments until 32 after birth (P32). Half of the animals of both groups were sacrificed for neuronal studies, and the remaining IC rats were housed under SC conditions for re-socialization between postnatal days 32 and 62. They were subsequently sacrificed for neuronal analysis. At both ontogenetic stages (P32 and P62) the dendritic development and the expression of calbindin-D28k (CBD) were studied in vermal Purkinje cells. The results obtained indicate that cerebellar Purkinje cells of IC animals show a significant dendritic atrophy associated with a reduction in the expression of CBD. In addition, the re-socialization process was able to restore the expression of CBD, but the structural impairment remained. Thus, the early adverse postnatal experiences induced by the social isolation model alter the morphological and functional development of vermal Purkinje cells

Palabras clave : adverse experiences; cerebellar development; dendritic arborization.

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