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Revista chilena de obstetricia y ginecología

On-line version ISSN 0717-7526


NUNEZ S, Alfredo; SCHWARZE M, Juan Enrique; VILLA V, Sonia  and  POMMER T, Ricardo. Importancia de alteración cromosómica en parejas, como causa de aborto recurrente: Revisión sistemática de la literatura. Rev. chil. obstet. ginecol. [online]. 2013, vol.78, n.6, pp.436-440. ISSN 0717-7526.

Objective: To determine the frequency of genetic alterations in couples with recurrent miscarriage. Methods: We searched articles in English in MEDLINE and PUBMED databases between 1990 and 2013, which reported karyotype analysis in couples with recurrent miscarriage and that had not been subjected to assisted reproduction techniques. Results: The frequency of chromosomal alterations differ among different studies, furthermore we found a significant variation in the number of patients included. Although articles studied used different numbers to define recurrent miscarriage, there were no significant differences in the frequency of genetic alterations among couples with at least 2 or at least 3 miscarriages. The reciprocal translocation alteration was the most frequently found genetic alteration. Chromosomal alterations were more frequent in women. Conclusion: Chromosomal analysis is essential in the study of couples with recurrent miscarriage. In those couples carriers of some alteration, is essential to perform a genetic counseling and should be offered prenatal diagnosis in future pregnancies.

Keywords : Female aging; fertility; recurrent miscarriage; karyotype analysis; genetic counseling.

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