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Revista chilena de obstetricia y ginecología

On-line version ISSN 0717-7526


MOLGO N, Montserrat et al. Síndrome de Cushing durante el embarazo: manifestaciones cutáneas secundarias a un tumor suprarrenal. Rev. chil. obstet. ginecol. [online]. 2013, vol.78, n.4, pp.320-324. ISSN 0717-7526.

Cushing's syndrome secondary to adrenal tumor is a rare pathology in pregnancy. Its presence results in a significant increase in maternal and fetal morbimortality. Many of its clinical features are masked by the typical changes of a physiological pregnancy, which make difficult the diagnosis. Indeed, skin manifestations may be useful in early clinical suspicion. We report a case of a 26 year old in the second trimester with severe inflammatory acne and hirsutism. The pregnancy is interrupted at 35 weeks for pregnancy-induced hypertension syndrome and premature rupture ovular membranes. During the puerperium, patient consulted a dermatologist presenting still the injuries described, as well as thick purple striae throughout the abdomen, moon face, truncal obesity and purpuric macules in pressure zones. Cushing's syndrome is diagnosed. The study showed a cortex suprarenal adenoma. Laboratory diagnosis is difficult because the pregnancy physical changes and routine laboratory findings that can mimic the disease themselves. Dermatological findings may be valuable for diagnosis and early treatment. The skin lesions secondary to hypercortisolism were difficult to manage.

Keywords : Pregnancy; hirsutism; acne; Cushing syndrome; adrenal adenoma.

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