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Revista chilena de obstetricia y ginecología

On-line version ISSN 0717-7526


BARRIOS G, Lía; BENEDETTI P, Inés  and  CONTRERAS B, Eusebio. p16INK4a como predictor de evolución clínica en pacientes con neoplasia intraepitelial cervical de bajo grado (NIC-I): serie de casos. Rev. chil. obstet. ginecol. [online]. 2012, vol.77, n.2, pp.106-110. ISSN 0717-7526.

The morphological diagnosis of low grade-cervical intraepithelial neoplasia (CIN-1) can not determine its true risk of progression to cervical cancer, leading to strict adherence to a high number of patients whose lesions, most will return spontaneously. The detection of p16INK4a has been proposed as biomarker to differentiate between productive infection self-limiting by human papillomavirus (HPV) and cell transformation induced by oncogenic strains of HPV, however, it is necessary provide evidence of its predictive capacity. We present a series of 14 cases of CIN-1 with immunohistochemical detection of p16INK4a in cervical biopsy (8 positive and 6 negative), whose retrospective review of medical records of more than 12 months of cyto-histopathological follow, can describe spontaneous regression in all cases p16INK4a negative and in 3 cases p16INK4a positive (37.5%). The findings in this series of cases coincide with that described in previous studies that has been demonstrated the negative predictive value of the marker to exclude risk of progression-persistence and avoid follow-ups and unnecessary treatments. Additionally, these indicates weaknesses to evaluate about the positive predictive value of the test, by not discriminating factors independent of cellular transformation, determining the progression-persistent CIN-1, such as genetic and / or immunologic variables of the host.

Keywords : p16INK4a; low grade-cervical intraepithelial neoplasia (CIN-1); cervical cancer.

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