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vol.74 issue4EVALUACIÓN NEONATAL DEL CRECIMIENTO INTRAUTERINO DE RECIÉN NACIDOS EN HOSPITAL REGIONAL DE TEMUCO: COMPARACION CON TRES ESTÁNDARES NACIONALESSOBREVIDA DE NEONATOS DE EXTREMO BAJO PESO AL NACER EN UNA REGIÓN DEL SUR DE CHILE author indexsubject indexarticles search
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Revista chilena de obstetricia y ginecología

Print version ISSN 0048-766XOn-line version ISSN 0717-7526

Abstract

VILCHEZ P, Desiree; PEREZ-AGUILAR, Mary Carmen; SABA K, Samir  and  BONFANTE-CABARCAS, Rafael. LOS NIVELES SÉRICOS DE ADENOSIN DEAMINASA Y ÁCIDO ÚRICO SE CORRELACIONAN EN PACIENTES GESTANTES CON TRASTORNOS HIPERTENSIVOS . Rev. chil. obstet. ginecol. [online]. 2009, vol.74, n.4, pp.217-224. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262009000400003.

Objective: To evaluate serum levels of the enzyme adenosine deaminase (ADA) in normal pregnant and patients with hypertensive disorders induced by pregnancy, in order to determine their relationship with the severity of the hypertensive disorder and with serum biochemical markers. Method: We evaluated patients with mild preeclampsia, severe preeclampsia, gestational hypertension and healthy pregnancy (n=10 per group). We determined the serum levels of ADA, uric acid, creatinine, ammonia and liver enzymes. Results: In patients with preeclampsia and gestational hypertension we detected a rise in serum ADA as compared with those who had undergone a normal pregnancy. ADA levels were positively correlated with uric acid and creatinine serum levels, but not with clinical severity. Uric acid levels were associated with serum creatinine and the clinical severity of hypertensive disorders. We also found an increase in ammonia levels in patients with preeclampsia, which did not correlate with other biochemical markers, while the levels of SGOT, SGPT, and LDH were significantly elevated in severe preeclampsia. Conclusion: This study establishes a link between the activity of ADA with hypertensive disorders of pregnancy, high levels of ammonium with preeclampsia and uric acid, SGOT, SGPT and LDH levels with the severity of hypertensive disorders.

Keywords : Adenosine deaminase; preeclampsia; gestational hypertension; uric acid; ammonia.

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