Abstract

MARTINEZ RM, Alejandra et al. FACTORES PRONÓSTICOS DEL CARCINOMA DUCTAL IN SITU DE MAMA. Rev. chil. obstet. ginecol. [online]. 2008, vol.73, n.1, pp.35-41. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262008000100007.

Objective: The primary endpoint of our study was to evalúate the impact of Van Nuys Prognostic índex (VNPI) on recurrence of the breast ductal carcinoma in situ (DCIS). Secondary endpoints included other histologic features: size, nuclear grade, necrosis and architectural pattern, disease-free survival and ove-rail survival. Methods: Datábase of the breast unit was searched for patients with DCIS diagnose between January 1995 and December 2000. Clinical data, mammographic findings, pathological features, outcome and prognosis were studied. Results: Ninty five DCIS were detected at our center between 1995-2000, but only 79 patients were included in the statistical analysis. The incidence was 7.1% over the total number of breast cancers. Diagnose was made by a screening mammography in the majority of cases, and presence of microcalcifications was the most frequent mammographic finding. None of the clinical variables was asso-ciated to bigger rates of relapse. Tumour size, high grade and necrosis and VNPI had a significant associa-tion with recurrence. Conclusions: Disease outcomes are very diverse, and it is necessary to consider DCIS as different entities, more than as an isolated disease. Biologic and histological factors, mainly VNPI, allow to stratify patients according to their risk and help to individualize treatment

Keywords : Ductal carcinoma in situ of the breast; Van Nuys prognostic Índex.

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