Abstract

IRRIBARRA A, Cristina; ALMUNA V, Ramón; AEDO M, Sócrates  and  PORCILE J, Arnaldo. TESTOSTERONA SÉRICA EN TRASTORNOS HIPERTENSIVOS DEL EMBARAZO. Rev. chil. obstet. ginecol. [online]. 2007, vol.72, n.1, pp.33-37. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262007000100006.

Objective: Association between hyperandrogenemia and preeclampsia was communicated. This study was designed to explain if also there is association between hyperandrogenemia and pregnant with essential chronic arterial hypertension (HACE). Methods: To 45 women with gestation of third trimester were separated in 3 groups: 1) normal arterial pressure (n=15), 2) preeclampsia (n=16), 3) HACE (n=14). It was registered age, parity, body mass index (IMC), systolic and diastolic arterial pressure (mm of Hg), proteinuria in 24 h, weeks of gestation, and seric level of total testosterone (Tt), free testosterone (Tl), free androgen index (IAL). Results: The studied groups, normal arterial pressure, preeclampsia, and HACE, displayed the following serics values, respectively: Tt (nmol/L) 2.3±1.4; 5.2±3.0; 1.9±1.5; (p=0.001). IAL (pmol/L) 0.5±0.3; 1.1±0.9; 0.4±0.2; (p=0.001). Not significant differences were found in: Tl (pmol/L) 7.2±4.7; 7.4±4.5; 4.5±2.6. SHBG (nmol/L) 468±112; 503±134; 512±96. Conclusions: The pregnant women with HACE presented similar seric level of T than pregnant women with normal arterial pressure. However, the women with preeclampsia displayed significant increased levels of seric Tt and increased IAL. We conclude that the association observed of hyperandrogenemia with preeclampsia was not found in pregnant with HACE

Keywords : Preeclampsia; hyperandrogenemia; testosterone.

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