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Revista chilena de nutrición

versión On-line ISSN 0717-7518

Resumen

SOUZA, Suene Vanessa da Silva et al. Polydextrose consumption prevents obesity and comorbidities in rats fed with a hypercaloric diet. Rev. chil. nutr. [online]. 2020, vol.47, n.1, pp.6-13. ISSN 0717-7518.  http://dx.doi.org/10.4067/S0717-75182020000100006.

The aim of this study was to evaluate the effect of different polydextrose concentrations for the prevention of obesity and its comorbidities in rats fed a high calorie diet. Thirty male Wistar rats were used. Rats were divided into 4 groups: Control group (HC) and 3 groups which received a hypercaloric diet with 2%, 4% and 6% polydextrose supplementation (HC2%P, HC4%P and HC6%P, respectively). The hypercaloric diet used was of the cafeteria type to induce obesity. Body weight and feed intake were verified weekly. Glucose and insulin tolerance tests were performed five days before finalizing the experiment. At the end of the experiment, animals were euthanized for blood collection, anthropometric measurements and tissue weighing. Polydextrose significantly decreased weight, body fat, blood glucose, triglycerides, glucose intolerance and insulin resistance and increased HDL cholesterol levels. The use of polydextrose reduced the complications of obesity in mice fed a hypercaloric diet. In conclusion, polydextrose may be a promising treatment for controlling obesity, diabetes type II and cardiovascular diseases.

Palabras clave : Diabetes; Obesity; Polydextrose; Prebiotics; Rats.

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