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Revista chilena de nutrición

versión On-line ISSN 0717-7518


ORELLANA, Paula; VALENZUELA, Rodrigo; VALENZUELA, Alfonso  y  MORALES, Gladys I. Neuroprotective effects of arachidonic and docosahexaenoic acid in the extreme stages of life: An integrative view. Rev. chil. nutr. [online]. 2018, vol.45, n.1, pp.80-88. ISSN 0717-7518.

The study focused on elucidating the neuro-protective effects of ARA and DHA throughout the life cycle has become of increasingly interest since the continue discovering of mechanisms by which these long-chain polyunsaturated fatty acids (LCPUFA) modulate the metabolism. Both ARA and DHA are deposited into the membrane lipids of the cells that form the gray matter of the brain and represent approximately 25% of the total content of cerebral fatty acids. ARA and DHA have effects on the growth and neuronal differentiation through the modulation of the physical properties of the membrane, the signal transduction associated to G proteins and by the modulation of gene expression, acquiring a relevant role in neurogenesis and brain development. In addition, it is attributed to these fatty acids a neuro-protective role in neurodegenerative pathologies such as Alzheimer's disease and Parkinson's disease by decreasing the mitochondrial dysfunction, neuroinflammation and oxidative stress, characteristic of these pathologies. This review analyzes and discusses the role of ARA and DHA in neuro-protection and neuro-degeneration through an integrative vision.

Palabras clave : Arachidonic acid; Docosahexaenoic acid; Neuro-protection; Neuro-degeneration; Alzheimer's disease; Parkinson's disease.

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