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vol.31 número1ACTIVIDAD DE DISTINTAS PRESENTACIONES COMERCIALES DE SACCHAROMYCES BOULARDIIADECUADO USO DEL PERÍMETRO CEFÁLICO DE LACTANTES EN SUS CONTROLES DE SALUD índice de autoresíndice de materiabúsqueda de artículos
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Revista chilena de nutrición

versión On-line ISSN 0717-7518

Resumen

MUZZO B, Santiago et al. BONE MINERALIZATION IN PATIENTS WITH HEPATIC INSUFICIENCY. Rev. chil. nutr. [online]. 2004, vol.31, n.1, pp.40-45. ISSN 0717-7518.  http://dx.doi.org/10.4067/S0717-75182004000100005.

Chronic hepatic insuficiency (HI) alters bone mineralization according to the etiology of HI, to the secondary nutritional problems and to the post transplant treatment with immunosupressors and glucocorticoids. The objective of this study was to know the characteristics of bone mineralization by bone densitometry in children with HI secondary to biliary ducts atresia and bone formation and resorption throught seric osteocalcine and urinary pyridinolines measurement. The age of patients ranged from 7 months to 14 years. Percentaje of BMI adequation was 102.1± 6.7 kg/m2, height for age z score -0.53±1.06; L2-L4 Bone Mineral Density (BMD) -2.48±1.23 g/cm2, seric osteocalcine was 44.1±13.9 ng/dL decreased in 8/8 patients; calcium urinary excretion 3.8±3.3 mMCa/mM creatinine increased in 5/8patients and D-piridinolines 39.9±25.0 mMDPir/mMcretinine increased in 8/8 patients. It is concluded that patients with HI present before liver transplant an early defici of bone mineralization, with low bone formation and high resorption markers. This situation could be worsened after transplant with the glucocorticoid treatment, what must be prevented through a nutritional intervention, increasing physical activity and by an adequate pharmacologic treatment

Palabras clave : Hepatic insufficiency; bone mineral density; osteocalcine; piridolidines; children.

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