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Revista chilena de enfermedades respiratorias

versión On-line ISSN 0717-7348

Resumen

SEPULVEDA-LOYOLA, Walter; SERGIO, Paulo  y  PROBST, Vanessa Suziane. Pathophysiological mechanism of sarcopenia in COPD. Rev. chil. enferm. respir. [online]. 2019, vol.35, n.2, pp.124-132. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482019000200124.

Sarcopenia is a disease characterized by loss of skeletal muscle, muscle strength and physical performance, being the major cause of frailty in the elderly. The sarcopenia is highly prevalent in individuals with Chronic obstructive pulmonary disease (COPD) leading to a poor prognosis and higher mortality in this population. The presence of sarcopenia in COPD is likely the result by the interaction between external and internal factors as systemic inflammation, oxidative stress and genetic polymorphisms, frequently observed in individuals with this respiratory disease. This review summarizes the current knowledge about the pathogenic mechanisms linking COPD with sarcopenia.

Palabras clave : Sarcopenia; pulmonary disease chronic obstructive; oxidative stress; inflammation; polymorphisms genetic.

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