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Revista chilena de enfermedades respiratorias

On-line version ISSN 0717-7348

Abstract

LOZANO C, Jaime et al. Severe asthma in children: A different phenotype?. Rev. chil. enferm. respir. [online]. 2012, vol.28, n.4, pp.272-276. ISSN 0717-7348.  http://dx.doi.org/10.4067/S0717-73482012000400002.

Background: The magnitude of response to treatment of asthma exacerbations is variable and a significant proportion of them need hospitalization. Objectives: to define the profile of children that were hospitalized for severe asthma and the possible indicators and determinants of their poor responsiveness. Methods: a prospective study in 60 children 4 years or more of age with a search of the ethiology of the exacerbation and a study of the inflammatory profile in sputum. Results: 60 children between 4 and 15 years. 50% had a previous diagnosis of asthma without regular use of inhaled corticosteroids in two thirds. 40% had previous admissions for asthma. Etiology of the exacerbation was identified in 52% with Rhinovirus, human Metapneumovirus, RSV and Mycoplasma pneumoniae as the most frequent agents. Inflammatory profile was determined in 33 children: eosinophilic in 36%, eosinophilic/ neutrophilic in 64%. Conclusions: Severe asthma with serious exacerbations may be a phenotype whose outstanding aspects in this cohort were: previous hospitalizations, lack of prophylactic treatment, viral infections as frequent trigger, and combined inflammatory cell profile in sputum.

Keywords : Severe asthma; children; viral respiratory infections; eosinophilic/neutrophilic inflammation.

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