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Revista chilena de enfermedades respiratorias

On-line version ISSN 0717-7348


ZAGOLIN B, MÓNICA et al. Acute vasodilatador test using adenosine in patients with pulmonary arterial hypertension: Prevalence and clinical, functional and hemodynamic response after diltiazem treatment. Rev. chil. enferm. respir. [online]. 2009, vol.25, n.1, pp.8-14. ISSN 0717-7348.

Pulmonary arterial hypertension (PAH) is a severe and progressive disease. Invasive hemodynamic study (HS) is required to confirm the diagnosis of PAH and to perform the vasodilator test (VT) with adenosine. Vasodilator acute responders (VAR) may have a sustained benefit with diltiazem. There is not national information regarding these issues. All patients with probable PAH were evaluated with HS and VT. VAR were treated with diltiazem and followed up with functional class score (FC) and 6 minute walk test. After 6 months, a second HS was performed. Results: Between 2003 and 2008, 6/54 (11%) were VAR. All were women, 45 ± 14 years oíd, 4 with idiopathic PAH, 4 in FCIII and 2 in FCII. After two years of treatment, all patients clinically improved. Walked distance significantly increased by 83 and 87 m at month 12 and 24 respectively. Hemodynamic parameters also improved. Therapy with diltiazem is effective in VAR patients supporting the convenience to perform the VT.

Keywords : Pulmonary arterial hypertension; vasodilator challenge; calcium channel blockers; diltiazem.

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